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How to easily memorize Gluconeogenesis

An easy way to learn and memorize gluconeogenesis is by using mnemonics to help you remember the order of molecules. Since Gluconeogenesis (generation of glucose) is the opposite pathway of glycolysis, all of the molecules should be familiar if you have studied glycolysis in the past. See my review of Glycolysis and where it occurs if you are not familiar with the molecules.


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The phrase I use to memorize gluconeogenesis is:

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Repeat the Mnemonic Out Loud

You can use the mnemonic I came up with or create your own. The import thing is to practice out loud. Over time you will eventually be able to recite the molecules of gluconeogenesis without using the mnemonic phrases.

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Why we have Gluconeogenesis?

When you consume foods classified as good sources of carbohydrates or starches (sugars), these foods are primarily composed of complex formations of glucose molecules.

Foods high in carbohydrates like bread are primarily composed of complex chains of Glucose. Water is also abundant and will be consumed when the bread is converted into energy.

In order to produce cellular energy from consumed carbohydrates, each glucose molecule is broken down into pyruvate or lactic acid during the first stage of cellular respiration (Glycolysis). The products of glycolysis can then be used in the second stage (Citric Acid Cycle) and third stage (Electron Transport Chain) of cellular respiration to make significantly more energy for cells.

However, if too much glucose is converted into energy there must be a way to convert the downstream products back into glucose. Many times your body may want to consume other energy sources such as fats and store them as glucose. For example, your brain only uses glucose as an energy source. If blood sugar level are low your body can convert other carbon sources such as fats and proteins into glucose and your brain will not starve.

The process of gluconeogenesis and glycolysis are opposing yet balancing processes that facilitate homeostasis.

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